The effects of hypoxia, HIF, and Notch in regulating early hemangioblast development

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the survey of the virtual higher education in iran and the ways of its development and improvement

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Hypoxia affects mesoderm and enhances hemangioblast specification during early development.

Hypoxia Inducible Factor (HIF), consisting of HIF1alpha and ARNT (HIF1beta) subunits, activates multiple genes in response to oxygen (O(2)) deprivation. Arnt(-/-) mice exhibit substantial defects in blood cell and vessel development. We demonstrate that hypoxia accelerates the expression of Brachyury (a mesoderm-specific transcription factor), BMP4 (a mesoderm-promoting growth factor) and FLK1 ...

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ژورنال

عنوان ژورنال: The FASEB Journal

سال: 2007

ISSN: 0892-6638,1530-6860

DOI: 10.1096/fasebj.21.5.a185-b